Discover Most Welcoming Cities of South America for Your First Visit
From the mystic Andes to sun-kissed beaches, South America is a continent bursting with color, culture, and charisma. If you’re planning your first trip, choosing the right cities can make your experience unforgettable. Here’s a curated list of the Top 10 South American cities for first-time travelers, offering the perfect blend of adventure, safety, culture, and local charm—plus a few lesser-known secrets to enrich your journey.
1. Cusco, Peru
Gateway to Machu Picchu and ancient Incan heritage
More than just a pitstop en route to Machu Picchu, Cusco is a history lover’s paradise. Cobblestone streets, baroque cathedrals, and Incan walls tell stories centuries old. The San Pedro Market is a sensory overload, and the nearby Sacred Valley offers hidden gems like the Maras salt mines.
📝 Lesser-known tip: Visit during the Inti Raymi (Festival of the Sun) in June—a spectacular reenactment of Incan rituals that even many Peruvians haven’t witnessed.
2. Buenos Aires, Argentina
Europe meets Latin America in this tango-filled capital
Nicknamed the “Paris of South America,” Buenos Aires is ideal for first-timers who want a mix of familiarity and flair. From elegant neighborhoods like Recoleta to the vibrant street art of Palermo Soho, this city is romantic, electric, and affordable.
📝 Hidden gem: Explore the El Ateneo Grand Splendid—an old theatre turned into a bookstore. It’s been dubbed one of the most beautiful in the world.
3. Cartagena, Colombia
Colonial charm and Caribbean breeze
Cartagena is a postcard-perfect introduction to South America. Its walled city is alive with salsa rhythms, colorful balconies, and cobbled streets. The city is also one of the safest and most tourist-friendly in Colombia.
📝 Insider secret: For an uncrowded beach day, take a boat to Isla Barú early in the morning before the local crowd arrives.
4. Santiago, Chile
A cosmopolitan capital surrounded by nature
Santiago offers the best of both worlds—Andean views and urban vibes. The city has a polished metro system, great food scene, and proximity to world-class vineyards and the Andes mountains.
📝 Traveler tip: Take a day trip to Cajón del Maipo, a hidden canyon just an hour away, popular with locals but often overlooked by tourists.
5. Quito, Ecuador
Colonial core, modern soul—and right on the equator
As the world’s second-highest capital city, Quito is a breathtaking experience—literally and figuratively. The well-preserved Old Town is a UNESCO World Heritage site with stunning architecture.
📝 Unique experience: Straddle the equator at Mitad del Mundo, then visit the nearby Intiñan Museum for quirky, science-based exhibits on gravitational forces.
6. Lima, Peru
South America’s culinary capital
Lima is perfect for foodies. Known globally for its gastronomy, Lima offers everything from Michelin-level dining to flavorful street snacks like anticuchos and ceviche. The seaside district of Miraflores is great for first-time visitors.
📝 Bonus insight: Visit Huaca Pucllana—an ancient adobe pyramid in the heart of the city—for a mix of history and mystery.
7. Montevideo, Uruguay
Laid-back, artsy, and beach-laced
Montevideo often flies under the radar, but it’s a cultural gem with wide beaches, a thriving arts scene, and super friendly locals. It’s perfect for travelers looking for a slower pace but rich experiences.
📝 Lesser-known charm: Check out the Sunday Tristán Narvaja Market, a maze of antiques, street food, and local life.
8. La Paz, Bolivia
High-altitude thrills and local authenticity
La Paz is not for the faint of heart—literally. At 3,640 meters (11,942 ft) above sea level, it’s one of the highest cities in the world. But it’s also one of the most rewarding, with cable cars that double as public transport and access to Bolivia’s wild landscapes.
📝 Hidden adventure: The Moon Valley (Valle de la Luna), just outside the city, feels like a Martian desert and is relatively unknown to tourists.
9. Bogotá, Colombia
Art, altitude, and adrenaline
Bogotá is edgy, artistic, and fast-paced. It’s also a fantastic launchpad for exploring Colombia. Stroll through the graffiti-adorned La Candelaria, then take a cable car up to Monserrate for panoramic views of the city.
📝 Cultural tip: Don’t miss the Botero Museum—it’s free and offers a crash course in Colombia’s most celebrated (and voluminous) artist.
10. Salvador, Brazil
Afro-Brazilian soul and coastal beauty
Often overshadowed by Rio and São Paulo, Salvador is a vibrant cultural powerhouse. With its colorful colonial buildings, capoeira performances, and Afro-Brazilian cuisine, it’s a unique introduction to Brazil’s diverse roots.
📝 Secret spot: Visit the island of Itaparica—a quiet escape from the city’s rhythm with clear waters and fewer tourists.
Final Travel Tips for First-Timers In South America
Visa & Vaccines: Always check entry requirements and vaccination advisories before you go.
Altitude awareness: Cities like Cusco and La Paz are high-altitude—go slow and hydrate.
Cash is Still King
While credit and debit cards are widely accepted in major cities, small towns, local eateries, and markets often prefer cash. Carry small denominations in the local currency (like soles in Peru or pesos in Argentina).
Buy a Local SIM Card
Staying connected is essential for maps, translation, and safety. Local SIM cards are cheap and easy to get at airports or corner stores. Apps like WhatsApp are widely used for communication.
Pack for All Climates
South America spans diverse climates. You might need a swimsuit in Rio and a down jacket in Cusco—on the same trip! Layered clothing is key, especially if you’re moving between altitudes.
Use Reputable Transport
In some cities, official taxi apps like Cabify, InDrive, or Uber are safer than street taxis. Avoid night travel in rural areas and always book bus tickets through trusted providers.
Watch the Water
In many countries, tap water isn’t safe to drink. Stick to bottled or filtered water, and be cautious with ice or raw fruits from street vendors unless you’re sure they’re washed in safe water.
Learn Basic Phrases
Even a few words in Spanish or Portuguese can build trust and help in emergencies. Locals appreciate the effort and may go out of their way to help you.
Beware of Pickpockets
Especially in crowded tourist areas, public transport, and festivals. Use a money belt or crossbody bag, and don’t flash expensive items like cameras, jewelry, or phones.
Respect Local Culture
From indigenous traditions in the Andes to Afro-Brazilian rituals in Salvador, South America is culturally rich. Always ask before photographing people, especially in rural areas.
Ready for your first South American adventure? With cities that blend history, hospitality, and hidden gems, this vibrant continent is calling you.
